Which of the following drugs is NOT associated with Torsades de pointes?

Torsades de pointes (TdP) is a specific form of polymorphic ventricular tachycardia that can be triggered by several medications, especially those known to prolong the QT interval. Among the drugs listed, albuterol, which is a beta-agonist used primarily for asthma management, has not been shown to be associated with causing TdP.

Albuterol works by relaxing bronchial smooth muscle, leading to bronchodilation, and does not have significant effects on cardiac conduction or the QT interval. This distinguishes it from the other options provided.

In contrast, disopyramide, erythromycin, and haloperidol have all been implicated in causing TdP due to their potential to prolong the QT interval. Disopyramide, an antiarrhythmic, specifically can lead to increased risk of TdP because of its QT-prolonging effects. Erythromycin, an antibiotic, is also known to prolong the QT interval, particularly in patients with pre-existing risk factors. Haloperidol, an antipsychotic, is another medication associated with QT prolongation and increasing the risk of TdP.

Thus, the rationale for identifying albuterol as not being associated with TdP stems from its mechanism of action and lack of