Which of the following conditions is a hypercoagulable state that increases the risk of DVT?

Factor V Leiden is a genetic mutation that causes a hypercoagulable state, significantly increasing the risk of venous thromboembolism, including deep vein thrombosis (DVT). This condition arises due to a mutation in the factor V gene, leading to resistance against activated protein C, a key protein that normally helps to regulate blood clotting. As a result, individuals with Factor V Leiden have a higher tendency to form clots, particularly in the veins.

In contrast, coronary artery disease, chronic obstructive pulmonary disease, and asthma are not associated with intrinsic changes in the coagulation pathways that lead to a hypercoagulable state. While these conditions can impact overall health and may be associated with other complications, they do not directly increase the risk of DVT in the same manner as Factor V Leiden. Therefore, the presence of Factor V Leiden is significant in the context of hypercoagulability and its potential to lead to thrombosis.