Which combination of conditions commonly causes disseminated intravascular coagulation (DIC)?

Disseminated intravascular coagulation (DIC) is a serious condition characterized by the widespread activation of the coagulation cascade, leading to the formation of blood clots throughout the small blood vessels in the body. This can result in multiple organ dysfunction due to the depletion of platelets and clotting factors, subsequently causing bleeding complications.

The combination of snake bite, pregnancy, and sepsis is commonly associated with the development of DIC for several reasons. Snake bites can introduce venom that alters hemostasis and potentially triggers thrombotic events. Pregnancy can lead to a hypercoagulable state, especially in conditions such as preeclampsia or placental abruption, both of which can cause DIC. Sepsis is another well-known precipitating factor for DIC, as it often triggers a systemic inflammatory response that can activate the coagulation pathways.

In contrast to the other options, these three conditions are well-documented triggers of DIC, making this combination particularly relevant in clinical practice. Understanding these associations helps healthcare providers anticipate and manage the complications associated with DIC effectively.