What condition is defined by increased creatinine levels and decreased GFR?

The condition characterized by increased creatinine levels and decreased glomerular filtration rate (GFR) is acute renal failure, also known as acute kidney injury (AKI). In this condition, the kidneys suddenly become unable to filter waste products from the blood efficiently, leading to a rapid increase in blood creatinine levels. This impairment in kidney function results in reduced GFR, which is a crucial measure of kidney performance.

Acute renal failure can be caused by a variety of factors, including prerenal causes (such as decreased blood flow to the kidneys), intrinsic renal causes (such as damage to the kidney tissues due to nephrotoxins or ischemia), or postrenal causes (such as obstruction of urinary flow). The key features of this condition include the swift onset of symptoms and the potential for recovery if the underlying cause is addressed effectively.

In contrast, chronic renal failure develops over a longer period and is characterized by a gradual decline in kidney function, where elevated creatinine levels and decreased GFR are present due to long-standing conditions such as diabetes or hypertension. Prostatitis and pyelonephritis are both infections affecting the urinary tract and may result in acute kidney injury in severe cases, but they are not primarily defined by elevated creat